I have a similar problem - on a Windows 7 laptop, the Microbit setup manager can no longer see the RRC. I can manage the RRC over the web interface, and on a separate Windows 7 PC (where I did *not* install the Microbit virtual ports, just the Setup Manager, the setup utility *can* see the RRC and communicate.
On the laptop, I uninstalled/reinstalled the setup Utility, still can not see or communicate with the RRC.
John K3TN