It *may* work......take a look at the manual, page 130. There details are provided on
tested configurations, of which this is not one of them.
I personally would not use the FT-450, since it does not provide enough controls to control
the higher-end products. The lowest I would use is the FT-950. However, maybe someone
has experience with that rig with Yaesu Twin and can provide qualified feedback. It may be
adequate for your needs, that is a personal decision. I use two FT-2000's myself.
73,
Mitch DJ0QN / K7DX