I'm not too big on digital modes, but I've done some QSOs (just under 200 dxcc entities) via RemoteRig in the past year or so using RTTY, PSK31, PSK63, JT65 and JT9. I just use Audio Quality 2 - Linear 16 bits 8 kHz. I haven't experimented with better audio quality settings. I use Fldigi and wsjtx.
Marvin VE3VEE