Yes, no problem.
I have a "mk1" where my TS-480 radio is and a mkII in the "control centre".
And i also have a mkII where my TS-2000 is and "mk1" in the "control centre".
Just happened so that i could not find the right cables when i rebuilt my setup:-)
Just make sure you have the same firmware version on both.
LB9GE Trond