I do so:
at the remote site I have a PC running the remote service of HRD, connected to the radio via serial port and have the remoterig (radio site) conneted to the TTL port of the radio (RC2000 display port)
at the control site I have a PC running HRD connecting to the "remote" PC and have the RC2000 display connected to the remoterig (control site) TTL port.
Doing so I noticed that the radio control via the control PC running HRD is more reliable than connecting across remote rig serial link. Don't know why, I think the reason is something due to timing signals.
My connection speed is > 2Mbit over a wireless link. (ping about 1-2ms).
73, Steve